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Single-Dose Dexamethasone vs 5 Days of Prednisone in Acute Adult Asthma | PracticeUpdate - TAKE-HOME MESSAGE |
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Disclaimer » Advertising. Erik R. Hoefgen, Bin Huang, Christine L. Schuler, Carolyn M. Hosp Pediatr March ; 12 3 : — Dexamethasone is increasingly used for the management of children hospitalized with asthma in place of prednisone, yet data regarding the effectiveness of dexamethasone in children with asthma exacerbation severe enough to require hospitalization are limited.
Our objective is to compare the effectiveness of dexamethasone versus prednisone in children hospitalized with an asthma exacerbation on day reutilization. A covariate-balanced propensity score was derived to account for physician discretion in steroid selection.
A generalized linear model, including inverse probability treatment weighting, was used to detect differences in day return utilization unplanned readmission or emergency department visit between children whose first dose of corticosteroid was dexamethasone versus prednisone.
The total cohort had a mean age of 8. The covariate-balanced cohort had no significant differences in demographic characteristics or illness severity between groups. The dexamethasone group had a return utilization of 3. The propensity score-adjusted analysis revealed the steroid treatment was not found to significantly affect the day reutilization adjusted odds ratio [aOR] 1.
The initial steroid choice dexamethasone versus prednisone was not associated with day reutilization after hospitalization for an asthma exacerbation. Advertising Disclaimer ». Sign In or Create an Account. Search Close. Shopping Cart. Create Account. Advanced Search. Skip Nav Destination Article Navigation. Close mobile search navigation Article navigation. Volume 12, Issue 3. Previous Article Next Article. Article Navigation. Research Articles February 07 Hoefgen, MD, MS.
Louis, Missouri. Louis, MO This Site. Google Scholar. Christine L. Schuler, MD ; Christine L. Schuler, MD. Carolyn M. Kercsmar, MD ; Carolyn M. Kercsmar, MD. Katherine A. Auger, MD, MSc. Hosp Pediatr 12 3 : — Cite Icon Cite. Comments 0 Comments. Comments 0. View full article. Sign in Don't already have an account? Individual Login. Institutional Login. Sign in via OpenAthens. Pay-Per-View Access. Buy This Article. View Your Tokens. View Metrics. Citing articles via Google Scholar.
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If this email is not correct, please update your settings with your correct address. The email address you provided during registration, , does not appear to be valid. Please update your settings with a valid address before to continue using PracticeUpdate. Close Back. Sign in. Join now. Follow us on:. Search PracticeUpdate Cancel. While a single dose of dexamethasone did not demonstrate noninferiority to 5 days of prednisone for a mild to moderate exacerbation of asthma, outcomes appear comparable and further research may support the use of dexamethasone.
Primary Care Written by. Dexamethasone vs prednisone for asthma flare The duration of action of dexamethasone is three times as long as that of prednisone and lasts up to 72 hours; 5 mg of prednisone are equal to 0. Adult dosing of dexamethasone for various inflammatory conditions: Asthma exacerbation, 12 mg Multiple sclerosis exacerbation, 30 mg Allergic reaction, 8 mg High-altitude cerebral edema, 8 mg References Rehrer MW, Liu B, Rodriguez M, et al.
Ann Emerg Med. A cost-effectiveness analysis of dexamethasone versus prednisone in pediatric acute asthma exacerbations. Acad Emerg Med. This abstract is available on the publisher's site. METHODS Adult emergency department patients aged 18 to 55 years were randomized to receive either a single dose of 12 mg of oral dexamethasone with 4 days of placebo or a 5-day course of oral prednisone 60 mg a day.
Additional Info. National Library of Medicine. Become a PracticeUpdate member now. Further Reading. Skip to main content. Log in via OpenAthens. Log in using your username and password For personal accounts OR managers of institutional accounts.
Forgot your log in details? Register a new account? Forgot your user name or password? Search for this keyword. Advanced search. Latest content Current issue Archive Authors About. Log in via Institution. You are here Home Archive Volume 27, Issue 3 Two regimens of dexamethasone versus prednisolone for acute exacerbations in asthmatic Egyptian children. Email alerts. Article Text. Article menu.
Adults presenting to the emergency department with a mild or moderate exacerbation of asthma were randomized to receive a single dose of dexamethasone with 4 days of placebo or 5 days of oral prednisone.
Dexamethasone failed to demonstrate noninferiority to prednisone by a small margin for preventing relapse at 14 days; however, but there were similar rates of hospitalization for relapse and adverse events in the two groups.
The duration of action of dexamethasone is three times as long as that of prednisone and lasts up to 72 hours; 5 mg of prednisone are equal to 0. For adults with an asthma exacerbation, this study randomized patients to a one-time dose of 12 mg of dexamethasone orally followed by 4 days of placebo or 60 mg of prednisone daily for 5 days. The convenience of this dosing increased compliance, which improves the effectiveness of therapy reducing the cost for treating a relapse.
Oral and intramuscular injection of dexamethasone are equivalent. Oral dexamethasone demonstrates bioavailability similar to that of oral prednisone but has a longer half-life. We evaluate whether a single dose of oral dexamethasone plus 4 days of placebo is not inferior to 5 days of oral prednisone in treatment of adults with mild to moderate asthma exacerbations to prevent relapse defined as an unscheduled return visit for additional treatment for persistent or worsening asthma within 14 days.
Adult emergency department patients aged 18 to 55 years were randomized to receive either a single dose of 12 mg of oral dexamethasone with 4 days of placebo or a 5-day course of oral prednisone 60 mg a day. Outcomes including relapse were assessed by a follow-up telephone interview at 2 weeks. One hundred seventy-three dexamethasone and prednisone subjects completed the study regimen and telephone follow-up.
Subjects in the 2 groups had similar rates of hospitalization for their relapse visit dexamethasone 3. Adverse effect rates were generally the same in the 2 groups. A single dose of oral dexamethasone did not demonstrate noninferiority to prednisone for 5 days by a very small margin for treatment of adults with mild to moderate asthma exacerbations.
Enhanced compliance and convenience may support the use of dexamethasone regardless. Property Value Status. We have detected that you are using an Ad Blocker. PracticeUpdate is free to end users but we rely on advertising to fund our site. Please consider supporting PracticeUpdate by whitelisting us in your ad blocker. We have sent a message to the email address you have provided.
If this email is not correct, please update your settings with your correct address. The email address you provided during registration,does not appear to be valid. Please update your settings with a valid address before to continue using PracticeUpdate. Close Back. Sign in. Join now. Follow us on:. Search PracticeUpdate Cancel. While a single dose of dexamethasone did not demonstrate noninferiority to 5 days of prednisone for a mild to moderate exacerbation of asthma, outcomes appear comparable and further research may support the use of dexamethasone.
Primary Care Written by. Dexamethasone vs prednisone for asthma flare The duration of action of dexamethasone is three times as long as that of prednisone and lasts up to 72 hours; 5 mg of prednisone are equal to 0. Adult dosing of dexamethasone for various inflammatory conditions: Asthma exacerbation, 12 mg Multiple sclerosis exacerbation, 30 mg Allergic reaction, 8 mg High-altitude cerebral edema, 8 mg References Rehrer MW, Liu B, Rodriguez M, et al. Ann Emerg Med. A cost-effectiveness analysis of dexamethasone versus prednisone in pediatric acute asthma exacerbations.
Acad Emerg Med. This abstract is available on the publisher's site. METHODS Adult emergency department patients aged 18 to 55 years were randomized to receive either a single dose of 12 mg of oral dexamethasone with 4 days of placebo or a 5-day course of oral prednisone 60 mg a day. Additional Info. National Library of Medicine. Become a PracticeUpdate member now. Further Reading. Primary Care Primary Care.
localhost › GoodRx Health › Drug Classes › Corticosteroids. Dexamethasone is long-acting medication and is considered to be a potent, or strong, steroid. It is 6 times more potent (strong) than prednisone. Can prednisone. Findings of this meta-analysis shows that DEX is better than PRED in tolerability and as efficacious as PRED, which indicates that DEX is a suitable alternative. Dexamethasone's favorable side effect profile and pharmacokinetics compared with prednisone may mitigate poor adherence to longer steroid. The main differences between dexamethasone and prednisone are. Out of the potentially relevant articles, 10 were selected for full-text analysis Figure 1. Stopping a steroid too quickly can cause withdrawal symptoms such as extreme tiredness, weakness, lightheadedness, body aches, joint pain, nausea, and appetite loss. Patients taking an anticoagulantsuch as warfarin, should be monitored while taking steroid medication. However, when the results of Qureshi et al. Generic medications are more often covered by insurance, including Medicare and Medicaid. Different oral corticosteroid regimens for acute asthma.Introduction Asthma is one of the most prevalent chronic respiratory diseases, which often leads to an emergency department visit. Prednisolone is the most commonly used corticosteroid in treatment of asthma exacerbation. Oral dexamethasone demonstrates bioavailability similar to that of oral prednisolone but has a longer half-life. Objective To evaluate in adouble-blind,randomised clinical trial the efficacy of different doses of dexamethasone versus prednisolone in controlling asthma exacerbations in children.
Methods We recruited 60 patients with asthma exacerbation, aged 2—11 years. Participants were randomly divided into three groups 20 patients each. Group I received a single dose of oral dexamethasone 0. Vomiting, gastrointestinal tract cramps, ATAQ and relapse rate showed a non-statistically significant difference.
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Advanced search. Latest content Current issue Archive Authors About. Log in via Institution. You are here Home Archive Volume 27, Issue 3 Two regimens of dexamethasone versus prednisolone for acute exacerbations in asthmatic Egyptian children. Email alerts.
Article Text. Article menu. Original research. Two regimens of dexamethasone versus prednisolone for acute exacerbations in asthmatic Egyptian children. Abstract Introduction Asthma is one of the most prevalent chronic respiratory diseases, which often leads to an emergency department visit. Statistics from Altmetric. Read the full text or download the PDF:. Log in.
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