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Can You Take Prednisone With Azithromycin? | HelloPharmacist
Azithromycin (Oral Route) Precautions - Mayo Clinic - Can You Take Steroids and Antibiotics at the Same Time?
Study record managers: refer to the Data Element Definitions if submitting registration or results information. Bartonella henselae is the etiologic agent of cat scratch disease CSD. In most CSD cases resolution occurs in 2 to 3 months although a prolonged course often occurs. Data on the efficacy of antibiotic therapy in CSD is limited.
Azithromycin has been shown to have a small favorable effect in a small comparative study and is commonly prescribed for CSD, however its overall effect is not satisfactory. Corticosteroids may be effective in the treatment of CSD for the following reasons:. The total score will consist of the arithmetical summation of the 5 parameters. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. We're building a better ClinicalTrials. Check it out and tell us what you think!
Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Recruitment status was: Not yet recruiting First Posted : November 10, Last Update Posted : November 11, View this study on Beta. Study Description.
Corticosteroids may be effective in the treatment of CSD for the following reasons: Many experts believe that host response is involved in the pathogenesis of CSD and is responsible for the clinical manifestations rather than the direct effect of B. The absence of viable organisms in affected lymph nodes in the presence of positive PCR for B. Corticosteroids have been anecdotally reported to have been administered to patients with CSD, apparently with some success. The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD.
The study hypothesis is that corticosteroids will improve out come. Patients will be under followed up for 3 months. Major outcome measures will include duration of symptoms and signs, with particular emphasis on affected lymph node size and duration using a specific scoring system lymphadenitis score, LS. LS will be used to evaluate lymphadenitis at each follow-up visit.
The historical control group will be consisted of age, sex, and clinical manifestations-matched CSD patients who were treated with azithromycin without corticosteroids. Drug Information available for: Azithromycin Azithromycin dihydrate Azithromycin monohydrate. FDA Resources. Arms and Interventions. Intervention Details: Drug: prednison and azithromycin Patients with typical cat-scratch disease will be treated with a 5-day course of prednison and azithromycin. Outcome Measures.
Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Ability and willingness to comply with the protocol. Male and female patients aged years at the time of signing informed consent.
Patients with clinical manifestations consistent with early typical cat scratch disease lymphadenitis before spontaneous improvement has been recorded and before development of suppuration. Known history of allergy, hypersensitivity, or any serious reaction to azithromycin, other macrolides or corticosteroids. Patients for whom azithromycin or corticosteroids is contra-indicated. Current treatment with systemic corticosteroids. Patients with typical late cat scratch disease who has demonstrated constant improvement in the clinical manifestations of the involved lymph node.
Atypical cat scratch disease e. Endocarditis due to Bartonella sp.. Diabetes mellitus. Peptic ulcer disease or history of upper GI bleeding. History of inadequately treated tuberculosis or evidence of tuberculosis in the chest radiography. Schizoaffective disorder, anxiety or depression treated with antipsychiatric drugs, at present or in the past. Treatment with any investigational drug in any clinical trial within 30 days prior to administration of study medication.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information.
National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Cat-scratch Disease Bartonella Infections. Drug: prednison and azithromycin Drug: prednison, azithromycin Drug: prednison, Azenil. Phase 4. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. Study Start Date :. Estimated Primary Completion Date :. November 10, Key Record Dates.
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In our latest question and answer, our pharmacist discusses whether or not prednisone can safely be taken with azithromycin. I had COVID 6 days of moderate symptoms and was prescribed azithromycin, prednisone, famotidine, and fexofenadine, for allergies. Can I take all these together? Also, is it better to wait and start prednisone after the Z-Pack since affects some antibiotics?
Don't want to decrease the effect of antibiotics. Answered by Dr. All the drugs you listed in your question azithromycin, prednisone, famotidine, and fexofenadine are considered safe to take together as there is no reported interaction between them. I certainly understand your concern here with taking prednisone. Prednisone is the most commonly prescribed corticosteroid, and corticosteroids, as a class of drugs, are associated with immunosuppressionwhich is why you've probably heard not to take them with antibiotics since you are treating an infection with those.
Additionally, several studies have noted that individuals taking corticosteroids consistently, at high doses to treat certain inflammatory conditions such as rheumatoid arthritis, Crohn's, and ulcerative colitis are more at risk for certain infections due to the immunosuppression prednisone causes, namely:.
Having said all this, the dose of prednisone you are taking and how long you are taking it is highly relevant.
Although taking prednisone at any dose and duration can increase the risk of infection, generally, those who take high doses, consistently, are most at risk what a 'high dose' of prednisone is varies by source, but is generally around 40mg or more per day. Combining an antibiotic with prednisone for short-term treatment of a condition is really a question of if the positives outweigh the risks. Azithromycin and prednisone are very commonly prescribed together for the short-term treatment of conditions like sinusitis and bronchitis since the benefit of therapy generally outweighs the risk of complications from the combination.
In fact, one of the most commonly prescribed combinations of medications used for the short-term treatment of sinus infections is a Medrol Dose Pack which contains methylprednisolone, a similar steroid to prednisone and a Z-Pak azithromycin. Several studies have published results showing preliminary positive benefits with short-term use of the combination:.
The point here is that, yes, there are concerns with taking a corticosteroid and how it can suppress the immune system, which increases the risk of infection. However, for many individuals, a short-term course, at a relatively low dose of a steroid, is considered safe, with the benefits outweighing the risk.
It is more commonly those that are taking steroids on a daily basis, or at high doses or both that we are more concerned about. So, overall, there is no specific interaction between azithromycin and prednisone, and the drugs don't interfere with one another.
It's the conflict between immune suppression and treating an active infection that is the concern. As everyone's medical situation is different, I recommend talking to your doctor about what makes the most sense for you.
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Question I had COVID 6 days of moderate symptoms and was prescribed azithromycin, prednisone, famotidine, and fexofenadine, for allergies. Asked by Lane On Aug 13, Published Aug 16, Last updated Aug 16, Answer Thanks so much for reaching out to us and I hope that you are feeling better!
You specifically mentioned azithromycin and prednisone, so I do want to focus on that part. Azithromycin With Prednisone I certainly understand your concern here with taking prednisone. Additionally, several studies have noted that individuals taking corticosteroids consistently, at high doses to treat certain inflammatory conditions such as rheumatoid arthritis, Crohn's, and ulcerative colitis are more at risk for certain infections due to the immunosuppression prednisone causes, namely: Common viral infections e.
Staphylococcus aureus Common fungal infections Candida species Having said all this, the dose of prednisone you are taking and how long you are taking it is highly relevant.
Several studies have published results showing preliminary positive benefits with short-term use of the combination: Current evidence suggests that oral corticosteroids as an adjunctive therapy to oral antibiotics are effective for short-term relief of symptoms in acute sinusitis The point here is that, yes, there are concerns with taking a corticosteroid and how it can suppress the immune system, which increases the risk of infection.
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The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will. Prednisone, a corticosteroid, can suppress the immune system and. Some common types of oral corticosteroids are prednisone, methylprednisolone, dexamethasone, and cortisone. Antibiotics work a bit differently. No interactions were found between azithromycin and prednisone. However, this does not necessarily mean no interactions exist. the drugs in the study (prednisone, azithromycin or hydroxychloroquine). 1) or standard outpatient treatment plus prednisone (group 2). I was prescribed Bactrim for a skin infection that I have. This is meant to speed up your healing. Call your child's doctor right away if your child feels irritable or vomits after feeding. Several studies have published results showing preliminary positive benefits with short-term use of the combination:. For general information, Learn About Clinical Studies. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Use an effective form of birth control to keep from getting pregnant.In low doses, steroids can help ease joint pain from your RA. When taking a steroid, though, you need to be cautious about combining it with other medications, like antibiotics. Many people wonder: Is it okay to take antibiotics with steroids? Can the steroid enhance the antibiotic? We asked top medical experts to set the record straight about taking steroids and antibiotics together. Steroids also known as corticosteroids are medications that decrease inflammation in the body.
Doctors often prescribe them to treat joint inflammation and swelling, like that which results from RA. Steroids are also used to treat allergic reactions, help with breathing conditions such as asthma, and calm an overactive immune system in people with autoimmune diseases such as lupus and RA, where the immune system mistakenly attacks healthy tissue.
Some common types of oral corticosteroids are prednisone, methylprednisolone, dexamethasone, and cortisone. Antibiotics work a bit differently. So, for example, you might take an antibiotic to fight an infection such as strep throat, an ear infection, or a sinus infection.
There are many different classes and types of antibiotics; talk with your doctor about the right one for you. The answer to this question depends on the specific steroid, antibiotic, and the infection—but yes, in some cases, your physician may prescribe both drugs at the same time. The antibiotic targets bacteria and the steroid controls inflammation and resulting pain. For example, the steroid dexamethasone has proven effective in adults with bacterial meningitis, according to a study in The New England Journal of Medicine.
The two are also often prescribed together for certain infections. Still, there are some potential interactions you should be aware of when taking both oral steroids and antibiotics. Here are common ones to be mindful of. Always talk with your provider if you are unsure about drug interactions or have follow-up questions. There is a potential interaction between dexamethasone, a type of steroid, and certain antibiotics.
The antibiotic erythromycin can raise the amount of dexamethasone in your system, increasing your risk of side effects. All corticosteroids, including prednisone, carry the risk of interacting with quinolone antibiotics levofloxacin, ciprofloxacin and causing a tendon tissue that connects muscle to bone to rupture. Mixing prednisone and penicillin antibiotics such as amoxicillin is considered safe, says Madison.
Alcohol can increase your risk of side effects while on certain medications. You should avoid alcohol while taking certain antibiotics such as Flagyl metronidazole , Tindamax tinidazole , and Bactrim sulfamethoxazole. The combo can result in nausea, vomiting, rapid heart rate, and headaches. There are no known interactions between alcohol and steroids such as prednisone but drinking large amounts of alcohol may increase your side effects, including an upset stomach.
To be safe, avoid drinking while taking oral steroids or at the very least, limit your intake. Every drug carries a risk of side effects, and steroids and antibiotics are no different. But in the case of these two drugs, the gastrointestinal side effects can be worse when combined. For example, common side effects of antibiotics are nausea, diarrhea, and upset stomach. Corticosteroids can also cause an upset stomach and cramping , as they irritate the stomach lining.
So in short, combining antibiotics and steroids may increase the risk of stomach issues. This is meant to speed up your healing. Some research has suggested that the two medications work better together than either one alone in treating certain infections. For example, a recent review found that corticosteroids and antibiotics were more effective together in treating bacterial meningitis. Research on mice has also shown that taking steroids and antibiotics together improved recovery time for those with pneumonia.
Steroids, Antibiotics, and Meningitis: Plos One. Prednisone Uses and Interactions: MedlinePlus. Alcohol and Antibiotics: Mayo Clinic. Krista Bennett DeMaio has well over a decade of editorial experience. The former magazine-editor-turned-freelance writer regularly covers skincare, health, beauty, and lifestyle topics. Her work has appeared in national more. What can we help you find? Rheumatoid Arthritis. Research suggests the two might work better together to fight certain infections.
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